It is becoming increasingly clear that synaptic plasticity in pain-sensitive pathways has many features in common with better understood forms of synaptic plasticity, such as hippocampal long-term potentiation. Now Hartmann and colleagues have shown that AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, which are vital mediators of hippocampal plasticity, are also important modulators of inflammatory pain and of synaptic plasticity in the spinal nociceptive system.
Most AMPA receptors in the central nervous system — those that contain the GluRB subunit together with GluRA, C or D subunits — have low permeability to Ca2+. However, receptors that lack the GluRB subunit have much higher Ca2+ permeability, and many of these receptors are found in the spinal dorsal horn. AMPA receptors in the dorsal horn are also unusual in that they are found presynaptically on the axon terminals of primary sensory afferent neurons, and activation of these receptors depolarizes the afferent neurons and thereby reduces neurotransmission from afferent fibres to second-order neurons in the spine.
(Source: Signalling Gateway Org)
I concur. Plus, it hurts like fuck.
A new doodle and, I guess, poem. It’s been a pretty shitty day. 🙁
Tony Blair, earlier today.
This in via roving reporter, Paul Sellars:
Tony Blair has told MPs it would be “unwise and dangerous” for the UK to give up its nuclear weapons.
The prime minister outlined plans to spend up to £20bn on a new generation of submarines for Trident missiles.
Mr Blair said although the Cold War had ended the UK needed nuclear weapons as no-one could be sure another nuclear threat would not emerge in the future.
(Source: BBC News)
So, when we have the WMDs, that’s good! Anyone else – that’s bad! Never mind that these weapons are madness made metal, weapons so dreadful that their use would kill us along with any enemy.
But I guess Blair approves of this form of suicide bombing.
I love the way Butcher Blair thinks that some threat may turn up in the future and therefore it’s worth spending 65 THOUSAND MILLION POUNDS on countering this non-existent enemy.
There’s always money for war. And MPs.
But hospitals? Education? Public transport? Come off it – those aren’t priorities! What would you rather spend your taxes on, decent trains or some missiles that will poison the earth for thousands of years?
There’s only one response to Butcher Blair’s insane outburst:
I joined, for the first time in my life, a couple of weeks ago. I recommend you do the same before the mad fuckers blow us all to hell.
I’d love to see a microbe version of Blindddduh Date-uh…
I think these are in my parotid, biting me. 🙁